DEPARTMENT OF MATHEMATICAL AND STATISTICAL SCIENCES
UNIVERSITY OF ALBERTA

PIMS-MITACS MATHEMATICAL BIOLOGY SEMINAR

 

MONDAY, November 8, 2004
3:00 - 4:00 p.m.
CAB 657

 

Dr. Gary de Young
Department of Mathematics
King's University College

 

The De Young-Keizer model for Calcium Oscillations

Dr. Yulia Timofeeva (Heriot-Watt University) who recently (2003) complete her PhD thesis under Steven Coombes (Loughborough University) on "Oscillations and Waves in Single and Multi-cellular Systems with Free Calcium" state on her web site: "One of the more popular of the standard models underlying Ca2+ oscillations  between the ER and the cytosol is the biophysical De Young Keizer model based  around a detailed description of the dynamics for IP3 receptors (IP3Rs).  It is believed to be the first model that explains oscillations on the basis of only the IP3R/channel and a single Ca2+ pool."  A google web search  "De Young Keizer model calcium" quickly reveals about 150  works that directly reference the model.

The model was originally published in 1992 in the PNAS and as  illustrated above the model  has become important in understanding intercellular calcuim dynamics. Dr. De Young will discuss the development of the model on November 8 in the Mathbiology Seminar.  (The PNAS paper can be downloaded in pdf form from http://www.pnas.org/cgi/reprint/89/20/989).