DEPARTMENT OF MATHEMATICAL
& STATISTICAL SCIENCES
UNIVERSITY OF ALBERTA
MATHEMATICAL BIOLOGY SEMINAR
MONDAY SEPTEMBER 22, 2003.
Dr. Michael Li
Department of Mathematics and Statistical Sciences
University of Alberta
Immune Response to HTLV-I Infection and Backward Bifurcation
A mathematical model that describes the in vivo dynamics of the infection of CD4^+ T cells by the Human T-cell Lymphotropic Virus Type I (HTLV-I) is investigated. The model incorporates the initial antibody immune response to HTLV-I, and predicts the observed persistence of HTLV-I infection and a high proviral load. It also reveals a backward bifurcation which typically leads to catastrophic dynamics such as a sudden explosion of infected T cell population.
This is a joint research project with Horacio Gomez-Acevedo.