DEPARTMENT OF MATHEMATICAL & STATISTICAL SCIENCES
UNIVERSITY OF ALBERTA

  

MATHEMATICAL BIOLOGY SEMINAR
 

MONDAY SEPTEMBER 22, 2003.

3:00-4:00 p.m.

CAB 657
 

 

Dr. Michael Li

Department of Mathematics and Statistical Sciences
University of Alberta

 

Immune Response to HTLV-I Infection and Backward Bifurcation

 

Abstract:

 

A mathematical model that describes the in vivo dynamics of the infection of CD4^+ T cells by the Human T-cell Lymphotropic Virus Type I (HTLV-I) is investigated. The model incorporates the initial antibody immune response to HTLV-I, and predicts the observed persistence of HTLV-I infection and a high proviral load. It also reveals a backward bifurcation which typically leads to catastrophic dynamics such as a sudden explosion of infected T cell population.

 

 

This is a joint research project with Horacio Gomez-Acevedo.