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Volume 10,     Number 1,     Spring 2002

 

THE EFFECT OF SYNAPTIC DEPRESSION ON MODEL INHIBITORY NETWORKS
J. GRIGULL AND F. K. SKINNER

Abstract. Networks of inhibitory interneurons in the cortex generate synchronous rhythmic oscillations which are believed to critically control brain output. The temporal course of the inhibitory postsynaptic potentials is known to affect this synchronous activity in a variety of ways, in particular its stability and frequency. Here we investigate theoretically the effects of frequency-dependent synaptic inhibition on network dynamics. We show how this short-term synaptic plasticity in the form of synaptic depression confers stimulus-sensitivity on the network, and creates transition regimes between synchronous and asynchronous oscillatory patterns in which bursting patterns and bistability occurs. In this manner, inhibitory networks can add further dimensions to the control of the dynamical patterns produced by the brain.

 

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